Unearthing the evolution of innate immunity in a molecular, cellular and toxicological context

Predavač: Péter Engelmann, PhD, Associate Professor
Department of Immunology and Biotechnology, Clinical Center, University of Pécs, Pécs, Hungary
Predavanje će se održati u četvrtak 26.1.2017. u 11h u predavaonici 201.
Abstract
All living organisms maintain their homeostasis against environmental pathogens and endogenous malformations by innate immune mechanisms. Earthworm’s innate immunity is retained by molecular and cellular components. Cellular elements are the different subpopulations of migratory cells, so called coelomocytes that possess various immune functions.
Our major research goal is to study the evolution of innate immunity using Eisenia andrei earthworms as an invertebrate model system. In my lecture, I would like to give a broad overview concerning on the following topics of our interest:
We aimed to identify certain molecular markers to characterize the coelomocyte subpopulations and monitor their development and function applying in-house developed immune-biological tools so called monoclonal antibodies. In addition to this mechanistic point of view, we aimed to observe in details the coelomocyte-derived antimicrobial and cytotoxic processes. Furthermore, we aimed to unravel the conserved toxicological mechanisms and -possible- environmental impacts of engineered nanomaterials on innate immunity using a comparative approach.